ISR routine is not properly running

That’s what I’d expected. I’m using an even lower CPU clock in an FreeRTOS application and also handle a USART and other peripherals reliably.
This brings us back to the question what’s going on here :thinking: Strange…
NVIC prio grouping is disabled, too ? Using NVIC_SetPriorityGrouping(0);

BTW besides the good FreeRTOS documentation there is a good article here